The patch will work with both the standard and Game of the Year editions of Fallout 3 on Steam or GOG.
It also automatically loads FOSE when Fallout 3 is started (if it's installed) and enables the game to use 4GB of RAM: Some older Bethesda games, including Fallout 3, have a 2GB limit on RAM usage, and patching that up to 4GB can have a very positive impact on performance. Enter the Fallout Anniversary Patcher, by mod maker lStewieAl, which restores FOSE functionality by downgrading Fallout 3 to the pre-update version 1.7.0.3, while maintaining the removal of Games for Windows Live dependences.